An investigation on drug binding ability of cationic surfactant CTAB

Abstract

Taking in consideration the application of surfactants in drug delivery, the interactions of cationic surfactant cetyltrimethylammonium bromide (CTAB) with drug Betaine Hydrochloride have been scrutinized. The micellization behaviour of surfactant is investigated at three different temperatures (298.15, 308.15, and 318.15)K in presence of various concentrations (0.10, 0.25, and 0.50) mmolkg^-1 of drug Betaine hydrochloride via conductivity measurements The critical micelle concentration (CMC) obtained from conductivity measurements has been used to obtain various thermodynamic parameters of micellization i.e. standard free energy of micellization (ΔG⁰_m), standard enthalpy of micellization (ΔH⁰_m), and standard entropy of micellization (ΔS⁰_m). From CMC as a function of concentration of drug, it is witnessed that tendency of CTAB to form micelles increases in presence of drug.