Functionalized Iron oxide nanostructures: Recent advances in the Synthesis, characterization and electrochemical sensor applications: Functionalized Iron oxide nanostructures

Abstract

Biosensors play a significant role in the process of early diagnosis of non-communicable
disease. In global market biosensors are valued at over 25.5 billion USD in 2021. Screen
Printed Electrodes were traditionally used for biomolecule detection, but due to their poor
stability and low conducting properties, they have been replaced by Glassy Carbon Electrodes,
which exhibit excellent stability and reusability, only few works have been reported in glucose
detection. The objective of this review is to provide an overview on the synthesis iron oxide
nanoparticles and their composites developed for the electrochemical applications by various
research works. The iron oxide and their composites of suitable morphologies at nanoscale
dimensions prepared by various methods and conditions were compiled. The characterisation
results of all the samples obtained by X-Ray Diffraction, Scanning Electron Microscopy,
Fourier Transform Infrared Spectroscopy and Raman Spectroscopy were discussed in detail.
The sensing efficiency of nanoscale iron oxides, when they are functionalised/combined with
carbon nanotube, polyamidoamine dendrimer, Cellulose Nanocrystals, Terephthalic acid,
Polyaniline etc, were discussed in detail. The requirement for the development of more suitable
electrochemical sensors for glucose, ascorbic acid, dopamine and uric acid were proposed. The
most suitable functionality for the iron oxide to is proposed for the development of efficient
electrochemical sensor. Finally the review provides the summary of the iron oxide
nanomaterials, current challenges and future scope of electrochemical sensors.