Clinical Significance of Fibroblast Growth Factor Receptor Like 1 in Esophageal Cancer
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Abstract
Expression studies are directed to detect and quantify messenger RNA (mRNA) levels of a specific gene. In- silico expression aims at deciphering the molecular basis of disease and for the identification of biomolecules that drive the disease process[1] . Fibroblast growth factor receptor like 1 protein has been reported as a significant gene involved in major cellular processes and is shown to explicitly expressed in the human cancers[2]. A few enrichment analysis studies have investigated the association of FGFRL1 expression with tumorigenicity. Till now, little has been investigated regarding its biological function and expression particularly in esophageal cancer development. Recently, FGFRL1 was found to be in positive correlation with motility and tumorigenic potential of cells in esophageal squamous cell carcinoma [3].
In order to investigate the expression of FGFRL1 in esophageal carcinoma and its potential as prognostic marker, we studied the FGFRL1 mutation and expression profile. The FGFRL1 mutation data was analysed and compiled through COSMIC and cBioportal database. FGFRL1 was altered in <1% of total patients in esophageal squamous cell carcinoma and adenocarcinoma.
FGFRL1 expression profile was analysed using GEPIA and TNM plots[4-5] . Since mRNA expression level of FGFRL1 was found strongly high in ESCA tissues (num= 182) as compared to normal tissues (num=286) [Figure.02 and Figure .03].The survival analysis was done through KM-plotter[6-7]. We found that FGFRL1 can be regarded as a suitable prognostic biomarker for esophageal carcinoma. Fibroblast growth factor Receptor Like 1[FGFRL1] also reports high expression in adenocarcinoma subtype than normal tissues whereas conversely, its expression was downregulated in squamous cell carcinoma[Figure04].
The fifth FGFR , Fibroblast Growth Factor Receptor Like 1 shows positive effect on overall survival (OS) in samples and can also be a marker for Relapse Free survival of patients because of its high survival probability. The high FGFRL1 levels also contributes to longer overall and relapse free survival in esophageal squamous cell carcinoma. So , we concluded that high levels of FGFRL1 predict a better survival RFS time in both subtypes of esophageal carcinoma ,thus can be considered as diagnostic marker.
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