Preparation, characterization and biosensing applications of Ag doped La2O3/GO nanocomposites

Abstract

Dopamine is the prominent neurotransmitter having the concentration range 10-6
-10-9
in human blood.
The dopamine concentration imbalance may cause of several serious neurorological disease like
Parkinson’
s disease, dementia and Alzheimer. More over dopamine, the Alkali metal potassium is also
play conspicuous role in the neurotransmission that is known as Na-K Pump in biomedical science. The
rare earth metal like lanthanum is most applicable in the magnetic resonance imaging technique (MRI) for
the cancerous cell detection. Keeping in mind these prospective we synthesized the hybrid of La2O3
nonmaterial and K-complexes [(-4-N,N-dimethylamino benzoate-κO)(-4-N,N-dimethylamino
benzoic acid-κO) (4-N,N-dimethylamino benzoic acid-κO) potassium(I) coordination polymer)]
(Nano hybrid La2O3- K complex) by hydrothermal method. It has been further applied for the
immobilization of the enzyme tyrosinase (Tyr), which has been used for the electrochemical estimation of
dopamine biosensors. The structural, morphological and electrochemical estimation of synthesized
nanocomposites investigated by X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV- Visible
spectroscopy, Transmission electron microscopy (TEM), scanning electron microscopy (SEM), Atomic
force microscopy (AFM), and electrochemical techniques (CV & DPV). The electrochemical response
have been carried out for the Tyr/ La2O3- K/ITO bioelectrode observed linear detection range with high
sensitivity with low detection limit. The bioelectrode have been observed with low response time and
longer stability along with good repeatability. The strategy gives out novel results in the biosensing
applications.