Comparative analysis of X-ray Crystallographic Behavior of some Pyrazolone Derivatives: Comparative analysis of X-ray Crystallographic Behavior of some Pyrazolone Derivatives

Abstract

X-ray structural investigations have been compared for the three Pyrazolone derivatives,        (Z)-3-Methyl-1-phenyl-4-[(p-tolyl)(p-tolylamino)methylidene]-1H-pyrazol-5(4H)-one (I), (Z)-3-Methyl-4-[1-(4-methylanilino)-propylidene]-1-phenyl-1H-pyrazol-5(4H)-one (II) and (Z)-3-Methyl-4-((naphth-1-ylamino)methylidene)-1-phenyl-1H-pyrazol-5(4H)-one (III) respectively. The compounds (I), (II) and (III) were crystallizes in the monoclinic, triclinic and orthorhombic crystal system with space group P2₁/n, P-1 and P2₁2₁2₁ respectively. The pyrazole ring in all the three compounds is planar. In the crystal structure of compound (I), (II) and (III), the molecules are linked by an elaborate system of N-H···O hydrogen bonds. The crystal structures of all the three molecules were solved by direct method using single crystal X-ray diffraction data collected at room temperature and refined by full-matrix least-squares procedures. The X-ray crystallographic properties of these synthesized compounds of biological relevance are compared herein.