5-Fluorouracil induced chemoresistance in colorectal cancer and the role of bioactive molecules in chemosensitization

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Published Sep 14, 2021
Miguela Min Navis Kumar


Colon cancer is rated third in most diagnosed. The death rate due to colon cancer is estimated as 8% that is 608000 in approximation thus; around the world, it stands second in deaths due to cancer. By the year 2040, it is believed that a population of more than 1.5 crores will be in a need to undergo chemotherapy each year. The Preferred choice of treatment for benign to metastasis colon cancer includes chemotherapy but its use is limited by chemoresistance. The widely used drug of choice for treating cancers like colon, esophageal, stomach, pancreatic, cervical, and breast include 5-fluorouracil which is an antimetabolite that prevents cell proliferation and induces cytotoxic death. The major constraint of 5-FU is chemoresistance by overexpression of thymidylate synthase (TS), c- Yes/YAP, GLI 1, COX 2, β1 integrin, downregulation of p53, activation of MMR system, and initiation of cancer stem cells development. Chemoresistance by 5 FU can be attenuated by cotreating 5FU with natural bioactive compounds such as resveratrol, scutellarin, kaempferol, quercetin, and genistein that helps in sensitizing the resistance offered by tumor cells during chemotherapy. Since these compounds are less toxic and effective in presenting antitumor effects, it draws the attention of cancer researchers to build a better treatment for colon cancer.

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Navis Kumar, M. M. (2021). 5-Fluorouracil induced chemoresistance in colorectal cancer and the role of bioactive molecules in chemosensitization . SPAST Abstracts, 1(01). Retrieved from https://spast.org/techrep/article/view/309
Abstract 11 |

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5-Fluorouracil, Chemoresistance, Chemosensitization, Colon cancer, Natural bio-active compounds

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